Drug metabolism and pharmacokinetics dmpk is a scientific discipline once primarily associated with safety evaluation in drug development that has in the last two decades become a core discipline within drug discovery development and even post marketing. Pharmacokinetic studies pk studies are key activities of early drug developmentour pharmacokinetic screening pk screening can be exploratory or can be more extensivepk studies of a test article is an essential component of drug discovery and development programs to understand the pharmacokinetic properties. Role of pharmacokinetics and metabolism in drug discovery and development jiunn h lin and anthony y h lu pharmacological reviews december 1 1997 49 4 403 449. Ther into development both in vitro drug metabolism pharmacokinetics in drug discovery a primer for bioanalytical chemists part i in the face of advancing technology in combinatorial synthesis and high throughput screening the drug discovery process continues to evolve preclinical drug metabolism and pharmacokinetics studies play a key role. Adme and translational pharmacokinetics pharmacodynamics of therapeutic proteins applications in drug discovery and development read an excerpt table of contents o combines theoretical with practical aspects of adme in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small
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