Sample size determination in clinical trials with multiple co primary endpoints statistical principles for clinical trials multiple endpoint expert team phrma listed 20 we discuss the power and sample size determination . The determination of sample size is central to the design of randomised controlled trials1 to have scientific validity a clinical study must be appropriately designed to meet clearly defined objectives2 3 clinical trials should provide precise estimates of treatment effects thus allowing healthcare professionals to make informed decisions . Pris 679 kr hftad 2015 skickas inom 2 5 vardagar kp sample size determination in clinical trials with multiple endpoints av takashi sozu tomoyuki sugimoto toshimitsu hamasaki scott r evans p bokuscom. Sample size determination for clinical trials with co primary outcomes exponential event times toshimitsu hamasaki chin fu hsiao tim friede sample size determination for a specific region in multiregional clinical trials with scott r evans toshimitsu ochiai group sequential clinical trials with multiple co objectives 2016 . Sample size determination in clinical trials with multiple co primary endpoints takashi sozu phd kyoto university school of public health
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