Metastases determine malignancy the main attention so far has been focused upon organ metastases the molecular mechanisms thereof while far from being totally elucidated are increasingly well understood modern diagnostic tools now enable detection and precise localization of small lesions in. The therapeutic relevance of enhanced sensitivity in detection of lymph node metastases has to be considered in the light of in creased morbidity versus eventual prognostic improvements by modification of therapy. Lymphatic metastasis and sentinel lymphonodectomy recent results in cancer research pdf keywords read online and download pdf ebook lymphatic metastasis and sentinel lymphonodectomy recent results in cancer research. A sentinel lymph node biopsy slnb is a procedure in which the sentinel lymph node is identified removed and examined to determine whether cancer cells are present a negative slnb result suggests that cancer has not developed the ability to spread to nearby lymph nodes or other organs. Lymph nodes are often the first site of metastasis in a variety of cancers and are critical for tumor staging and prognosis 22 in prostate cancer for instance 75 of patients bearing lymph node metastases at the time of diagnosis will possess bone metastases within 5 years regardless of treatment 23 the presence of tumor cells in the bone
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