Who tumor response criteria and more recently recist response evaluation criteria in solid tumors have provided means to objectively measure tumor response in clinical trials with imaging these guidelines have been rapidly adopted in clinical practice to monitor patient treatment and for therapy planning. Cancer is a major human health problem and a completely effective therapy is not available for most types of cancer the expected benefit of the treatment is assessed in terms of a reduction in both the size of the tumor and dissemination of the cancer imaging is an ideal tool with which to . The treatment models employed in this work produced moderate treatment response only reducing tumor growth rates relative to untreated tumors but not dramatically changing tumor size fig 2b even with these moderate treatment effects a single post treatment imaging study was sufficient to determine the efficacy of chemotherapy fig 3 . In the therapy assessment setting multifunctional imaging can provide valuable information in a number of areas including a pretreatment prediction of tumor response b improved understanding of the biologic effects of therapy c predicting response early after initiating therapy d monitoring the effects of radiation and e . To evaluate tumor response to chemotherapy in vivo imaging was performed 1 day before and 1 day following the completion of treatment treatment outcome as reflected by change in tumor volume was compared in treated animals and nontreated controls
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